Lecture Repository - Cancer, Pathogenesis, Classification and Test for Treatment

The stem cell niche hypothesis

The stem cell niche hypothesis. (a) G6PD-stained frozen section of colonic mucosa from a CH3 mouse 14 days after a single dose of DMH showing a single wholly mutated crypt in which all cells have been replaced by a mutant phenotype (from ref.25, with permission). (b) Diagrammatic representation of the stem cell niche. An active multipotent stem cell (SC) produces a daughter cell (Co) that gives rise to enterocytic lineages, and another which generates goblet, Paneth, and enteroendocrine cells (although it is not known whether all derive from Mo). GLP-2 produced by a subset of enteroendocrine cells stimulates proliferation of the Co daughter via an interaction with enteric nervous system neurons that express the GLP-2 receptor (GLP-2R). The nature of the neuronal signal that affects Co is unknown (from ref.100 with permission)

Monoclonal origin of colonic crypts in an XO/XY patient

Robbins definition

A neoplasm is defined as a genetic disorder of cell growth that is triggered by acquired or less commonly inherited mutations affecting a single cell and its clonal progeny.

Cancer, Pathogenesis, Classification and Test for Treatment

The stem cell niche hypothesis

Monoclonal origin of colonic crypts in an XO/XY patient

Robbins definition

DNA methylation-based classification of central nervous system tumours

Sarcoma classification by DNA methylation profiling

SOLO2/ENGOT-Ov21 trial